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A New Cannabinoid-based Arthritis Therapy in the Making

Ryan Allway

August 19th, 2014

News, Top Story

Cannabinoids have been the focus of intense clinical research following the legalization of medical cannabis by several U.S. states. While pioneers like British-based GW Pharmaceuticals plc (NASDAQ: GWPH) have been actively studying cannabinoids since the 1990s, many North American companies haven’t started major research until recent years with compounds just starting clinical trials.

Cannabis Technologies Inc. (OTC: CANLF) (TSX-V: CAN) has been called the “junior GW” of the cannabis industry with its growing pipeline of cannabinoid-based therapies targeting a number of different conditions. On August 18, 2014, the company announced its second therapy, CTI-091, for the relief of joint pain and swelling associated with arthritis and joint disease.

Preliminary studies indicated that CTI-091 suppresses the human macrophage interleukin-6, a major inflammation biomarker, suggestive of strong scientific evidence that cannabis extracts reverse the disease progression. Once the company completes improvements to the delivery systems efficacy, management plans to complete pre-clinical trials and initiate Phase I clinical trials to assess the compound’s safety profile.

The market for effective arthritis treatments is enormous. With an estimated 50 million U.S. citizens suffering from arthritis or related diseases, several companies are targeting a piece of the estimated $35 billion global market. AstraZeneca plc’s (NYSE: AZN) and Amgen Inc.’s (NASDAQ: AMGN) brodalumab, for instance, is projected to peak at $0.5 billion to $1.5 billion in sales. This is a drop in the bucket compared to AbbVie Inc.’s (NYSE: ABBV) Humira, one of the leading sellers of all time regardless of indication.

“We are extremely pleased to announce a second therapy in our expanding product pipeline,” said Cannabis Technologies Inc. President and CEO Craig Schneider. “The pain and arthritis therapy takes our company to the next stage of development, reinforcing the proof of concept of our Cannabinoid Drug Design platform. This platform is designed to effectively identify and fast track new drug therapies.”

Cannabinoid Platform Technology

Cannabis Technologies’ proprietary Cannabinoid Drug Design Platform leverages the power of bioinformatics to identify individual compounds from the cannabis plant that can be targeted to develop therapies for specific diseases and conditions. While traditional drug development can take years, management aims to utilize the platform to dramatically reduce discovery time and accelerate development.

In addition to CTI-091, the company also leveraged the platform to fast track the development of CTI-085 for the treatment of glaucoma. The firm’s preclinical studies have shown that cannabinoids have the ability to lower intraocular pressure (“IOP”) in animal and could have therapeutic potential in the treatment of glaucoma, without many of the systemic side effects associated with other therapies.

ACADIA Pharmaceuticals Inc.’s (NASDAQ: ACAD) partnership with Allergan Inc. (NYSE: AGN) to develop Muscarinic for the treatment of glaucoma demonstrates the strong demand for a safe and viable treatment within the ~$5 billion per year industry. Many existing treatment options for glaucoma – particularly in the late stages – carry significant side effects for the patient.

Over the next twelve months, the company plans to announce numerous additional therapies focusing on areas like metabolic disease, orphan diseases and angiogenesis as it relates to cancer. These indications address markets worth many billions of dollars per year and capturing just a fraction of one of the markets could unlock significant value for the ~$11 million micro-cap company.

Pre-commercialization partnerships could unlock incremental value as the company’s drug development programs progress, too. While the cannabis industry is somewhat controversial, many large pharmaceutical companies are not opposed to partnerships. A great example is GW Pharmaceuticals’ partnership with the $100 billion Bayer AG (OTC: BAYRY) for its cannabinoid-based Sativex.

Investors in the pharmaceutical industry may want to pay closer attention to Cannabis Technologies’ – the “junior GW” – given its innovative platform technology and growing pipeline of therapeutics gearing up for Phase I clinical trials.

More Information

This article was published by CFN Enterprises Inc. (OTCQB: CNFN), owner and operator of CFN Media, the industry’s leading agency and digital financial media network dedicated to the burgeoning CBD and legal cannabis industries. Call +1 (833) 420-CNFN for more information.

About Ryan Allway

Mr. Allway has over a decade of experience in the financial markets as both a private investor and financial journalist. He has been actively involved in the cannabis industry since its inception, covering public and private companies.

Disclaimer: Except for the historical information presented herein, matters discussed in this article contain forward-looking statements that are subject to certain risks and uncertainties that could cause actual results to differ materially from any future results, performance or achievements expressed or implied by such statements. Emerging Growth LLC dba TDM Financial, which owns CannabisFN, is not registered with any financial or securities regulatory authority, and does not provide nor claims to provide investment advice or recommendations to readers of this release. Emerging Growth LLC dba TDM Financial, which owns CannabisFN, may from time to time have a position in the securities mentioned herein and will increase or decrease such positions without notice. For making specific investment decisions, readers should seek their own advice and that of their own professional advisers. Emerging Growth LLC dba TDM Financial, which owns CannabisFN, may be compensated for its Services in the form of cash-based and/or equity- based compensation in the companies it writes about, or a combination of the two. For full disclosure please visit: https://www.cannabisfn.com/legal-disclaimer/.

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About CFN Media Group

CFN Enterprises Inc. (OTCQB: CNFN) owns and operates CFN Media Group, the premier agency and financial media network reaching executives, entrepreneurs and consumers worldwide. Through its proprietary content creation, video library, and distribution via www.CannabisFN.com, CFN has built an extensive database of cannabis interest, assisting many of the world’s largest cannabis firms and CBD brands to build awareness and thrive. For more information, please visit www.cfnenterprisesinc.com.

Disclaimer: Matters discussed on this website contain forward-looking statements that are subject to certain risks and uncertainties that could cause actual results to differ materially from any future results, performance or achievements expressed or implied by such statements. CFN Media Group, which owns CannabisFN, is not registered with any financial or securities regulatory authority and does not provide nor claims to provide investment advice or recommendations to readers of this release. CFN Media Group, which owns CannabisFN, may from time-to-time have a position in the securities mentioned herein and will increase or decrease such positions without notice. The Information contains forward-looking statements, i.e. statements or discussions that constitute predictions, expectations, beliefs, plans, estimates, or projections as indicated by such words as "expects", "will", "anticipates", and "estimates"; therefore, you should proceed with extreme caution in relying upon such statements and conduct a full investigation of the Information and the Profiled Issuer as well as any such forward-looking statements. Any forward looking statements we make in the Information are limited to the time period in which they are made, and we do not undertake to update forward looking statements that may change at any time; The Information is presented only as a brief "snapshot" of the Profiled Issuer and should only be used, at most, and if at all, as a starting point for you to conduct a thorough investigation of the Profiled Issuer and its securities and to consult your financial, legal or other adviser(s) and avail yourself of the filings and information that may be accessed at www.sec.gov, www.pinksheets.com, www.otcmarkets.com or other electronic sources, including: (a) reviewing SEC periodic reports (Forms 10-Q and 10-K), reports of material events (Form 8-K), insider reports (Forms 3, 4, 5 and Schedule 13D); (b) reviewing Information and Disclosure Statements and unaudited financial reports filed with the Pink Sheets or www.otcmarkets.com; (c) obtaining and reviewing publicly available information contained in commonlyknown search engines such as Google; and (d) consulting investment guides at www.sec.gov and www.finra.com. You should always be cognizant that the Profiled Issuers may not be current in their reporting obligations with the SEC and OTCMarkets and/or have negative signs at www.otcmarkets.com (See section below titled "Risks Related to the Profiled Issuers, which provides additional information pertaining thereto). For making specific investment decisions, readers should seek their own advice and that of their own professional advisers. CFN Media Group, which owns CannabisFN, may be compensated for its Services in the form of cash-based and/or equity-based compensation in the companies it writes about, or a combination of the two. For full disclosure, please visit: https://www.cannabisfn.com/legal-disclaimer/. A short time after we acquire the securities of the foregoing company, we may publish the (favorable) information about the issuer referenced above advising others, including you, to purchase; and while doing so, we may sell the securities we acquired. In addition, a third-party shareholder compensating us may sell his or her shares of the issuer while we are publishing favorable information about the issuer. Except for the historical information presented herein, matters discussed in this article contain forward-looking statements that are subject to certain risks and uncertainties that could cause actual results to differ materially from any future results, performance or achievements expressed or implied by such statements. CFN Media Group, which owns CannabisFN, is not registered with any financial or securities regulatory authority, and does not provide nor claims to provide investment advice or recommendations to readers of this release. CFN Media Group, which owns CannabisFN, may from time to time have a position in the securities mentioned herein and will increase or decrease such positions without notice. For making specific investment decisions, readers should seek their own advice and that of their own professional advisers. CFN Media Group, which owns CannabisFN, may be compensated for its Services in the form of cash-based and/or equity- based compensation in the companies it writes about, or a combination of the two. For full disclosure please visit: https://www.cannabisfn.com/legal-disclaimer/.

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